Platencin is a natural, broad-spectrum Gram-positive antibiotic isolated from *S. platensis*, which is also the source of platensimycin. Platencin inhibits two key enzymes in bacterial fatty acid synthesis, beta-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 µg/ml, respectively. It does not exhibit cross-resistance to antibiotic-resistant bacterial strains, including methicillin-resistant *S. aureus*, vancomycin-intermediate *S. aureus*, and vancomycin-resistant Enterococci. For these reasons, platencin has potential applications in fighting antibiotic-resistant bacteria.
Molecular Weight:
425.481
CAS Number:
[869898-86-2]
Formula:
C24H27NO6
Target:
Antibacterial|||Others|||Antibiotic
T38125
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