Certain chronic neurologic disorders, such as Parkinsons disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(alpha-Linolenoyl) tyrosine (NALT) is a simple alpha-amide conjugate between the omega-3 essential fatty acid alpha-linolenate and the amino acid tyrosine. alpha-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinsons therapeutic agent.
Molecular Weight:
441.6
CAS Number:
[259143-19-6]
Formula:
C27H39NO4
Target:
Amino Acids and Derivatives
T38222
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