L-Sepiapterin is an activator of phenylalanine hydroxylase and also a synthetic precursor of tetrahydrobiopterin, a cofactor of endothelial nitric oxide synthase. L-Sepiapterin can improve endothelial dysfunction in mesenteric arterioles of db/db mice and induce angiogenesis, meanwhile, L-Sepiapterin can also inhibit the proliferation and migration of ovarian cancer cells by downregulating p70S6K-dependent VEGFR-2 expression. Based on the above biological activities, L-Sepiapterin can be applied to mechanistic studies related to hyperphenylalaninemia.
Molecular Weight:
237.22
Purity:
99.97%
CAS Number:
[17094-01-8]
Formula:
C9H11N5O3
Target:
Endogenous Metabolite
T38250
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