Alamethicin F50 is a peptaibol isolated from Trichoderma. It is a polymer of 20 amino acids that includes modified and non-proteinogenic amino acids. Alamethicin F50 is a mixture of 13 different peptides, with the most abundant designated as alamethicin F50/5. Alamethicin F50 forms voltage-dependent ion channels in lipid membranes and acts as a lytic agent. It induces lysis of leukocytes (IC50 = 54 and 80 µM for rat mast cells and mouse spleen lymphocytes, respectively) and exhibits antibacterial activity against a panel of 8 mollicutes (MICs = 1.56-12.5 µM).
Molecular Weight:
1963.32
CAS Number:
[56165-93-6]
Formula:
C92H151N23O24
Target:
Antifungal|||Antibacterial|||Others|||Antibiotic
T38296
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