CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS, IC50= 0.45 µM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-beta in THP-1 cells when used at concentrations of 10, 30, and 100 µM.
Molecular Weight:
371.13
CAS Number:
[2400954-16-5]
Formula:
C11H10IN5O2
Target:
Others|||cGAS
T38328
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