TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS, IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 µM, as well as over enzyme and receptor panels at 10 µM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sensitized guinea pig model of allergic rhinitis when administered at a dose of 30 mg/kg.
Molecular Weight:
526.638
CAS Number:
[1584160-52-0]
Formula:
C27H38N6O5
Target:
Others|||Prostaglandin Receptor
T38350
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