CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4, IC50= 0.71 µM), as well as class I histone deacetylases (HDACs, IC50s = 0.046, 0.058, 0.075, and 0.167 µM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 µM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 µM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 µM for all). CAY17c inhibits the proliferation of HCT116, SW620, and DLD-1 colorectal cancer cells (IC50s = 0.45, 1.78, and 2.11 µM, respectively), as well as induces apoptosis and autophagy in HCT116 cells. It reduces tumor growth in an HCT116 mouse xenograft model when administered at doses of 15 and 30 mg/kg.
Molecular Weight:
470.58
CAS Number:
[2414373-11-6]
Formula:
C24H30N4O4S
Target:
Others
T38381
* VAT and and shipping costs not included. Errors and price changes excepted
