MLK-IN-1 is a potent and selective mixed-lineage kinase 3 (MLK-3) inhibitor, showing excellent brain penetration and high specificity for MLK-3. MLK-IN-1 at 100 nM supports sustained axonogenesis in cultures challenged with HIV-1 Tat-activated microglia and protects neuronal cells from Tat-induced damage, establishing it as a valuable probe for neuroinflammation and neurodegeneration research.
Molecular Weight:
432.5
Purity:
99.74%
CAS Number:
[1627729-62-7]
Formula:
C23H20N4O3S
Target:
MLK
T39102
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