Telaglenastat (CB-839) hydrochloride is a first-in-class, reversible, and orally active inhibitor of glutaminase 1 (GLS1), selectively inhibiting the splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C), as opposed to GLS2. Telaglenastat hydrochloride has an IC50 of 23 nM for endogenous glutaminase in mouse kidney and 28 nM in the brain, inducing autophagy and exhibiting antitumor activity.
Molecular Weight:
608.04
CAS Number:
[1874231-60-3]
Formula:
C26H25ClF3N7O3S
Target:
Others|||Glutaminase|||Autophagy
T39309
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