1. beta,beta-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-kappaB pathway.
Molecular Weight:
370.396
Purity:
93.42%
CAS Number:
[24502-79-2]
Formula:
C21H22O6
Target:
NO Synthase|||ERK|||Apoptosis|||Bcl-2 Family|||HIF/HIF Prolyl-Hydroxylase|||Gamma-secretase
T3S2344
T3S2344
T3S2344
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