SHP2-D26 is a highly potent and effective SHP2 degrader that induces targeted SHP2 protein degradation through simultaneous binding to VHL-1 and SHP2, with degradation strictly dependent on neddylation and proteasome activity, thereby providing a powerful chemical biology tool for dissecting SHP2-driven signaling networks in cancer and immune regulation.
Molecular Weight:
1115.9
CAS Number:
[2458219-65-1]
Formula:
C56H79ClN12O6S2
Target:
Phosphatase|||PROTACs
T40121
T40121
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