CAY10602 is a SIRT1 activator derived from high throughput screening for compounds that enhance SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays indicate that CAY10602 dose-dependently suppresses NF-kappaB-dependent induction of TNF-alpha by lipopolysaccharide in THP-1 cells, achieving approximately 75% inhibition at 60 µM without cytotoxicity.
Molecular Weight:
418.44
Purity:
98.87%
CAS Number:
[374922-43-7]
Formula:
C22H15FN4O2S
Target:
Sirtuin
T4062
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