Helianorphin-19 is a high affinity, potent and selective kappa-opioid receptor (KOR) agonist (Ki = 25 nM, EC50= 45 nM). Helianorphin-19 exhibits approximately 200-fold selectivity for KOR over µ and delta-opioid receptors.In vivoHelianorphin-19 shows potent peripheral analgesic efficacy in a mouse model of visceral pain without affecting motor coordination/sedation.
Target:
Opioid Receptor
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