Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite derived from dietary choline, betaine, and carnitine. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation through the activation of the TGF-beta/Smad2 signaling pathway. TMAO is commonly used to induce cardiac fibrosis models.
Molecular Weight:
75.11
Purity:
98.00%
CAS Number:
[1184-78-7]
Formula:
C3H9NO
Target:
TGF-beta/Smad|||NOD-like Receptor (NLR)|||Reactive Oxygen Species
T41245
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