12(S)-HHT (12(S)-HHTrE), a fatty acid produced via the arachidonic acid metabolic pathway of cyclooxygenase (COX), is an endogenous ligand and agonist of BLT2, and the 12(S)-HHT/BLT2 axis plays a role in the maintenance of homeostatic aspects of epithelial tissues and in inflammatory responses. 12(S)-HHT inhibits the p38 MAPK/NF-kappaB pathway through upregulation of MKP-1, leading to reduced IL-6 synthesis in UVB-irradiated HaCaT cells.
Molecular Weight:
280.4
Purity:
98.45%
CAS Number:
[54397-84-1]
Formula:
C17H28O3
Target:
Endogenous Metabolite|||Leukotriene Receptor
T41365
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