JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 µM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.
Molecular Weight:
323.35
Purity:
99.50%
CAS Number:
[942655-44-9]
Formula:
C18H17N3O3
Target:
VEGFR|||FGFR
T4425
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