Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1, hypoxia inducible factor alpha, and inducible nitric oxide synthase, which contributes to oxidative stress and restored sirtuin 1/AMP-activated protein kinase/peroxisome proliferator-activated receptor-gamma coactivator-1alpha pathway-associated fatty acid oxidation in chronic ethanol-fed mice.
Molecular Weight:
324.35
Purity:
98.05%
CAS Number:
[25459-91-0]
Formula:
C19H18NO4
Target:
AMPK|||NF-kappaB|||NOS|||HIF|||Cytochromes P450
T4S0800
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