YZ129, a glioblastoma inhibitor, targets the HSP90-calcineurin-NFAT pathway by directly binding to heat shock protein 90 (HSP90) and exhibits an IC 50 of 820 nM on NFAT nuclear translocation. It induces cell-cycle arrest at the G2/M phase in GBM cells, leading to apoptosis and inhibiting tumor cell proliferation and migration [1].
Molecular Weight:
300.31
CAS Number:
[1643120-60-8]
Formula:
C19H12N2O2
Target:
Others|||Apoptosis|||HSP
T5339
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