VB124 is an orally active, potent and selective MCT4 inhibitor. VB124 blocked lactate import (IC50 value of 8.6 nM) and export (IC50 value of 19 nM) in MDA-MB-231 cells. VB124 is selective for MCT4 over MCT1 and shows minimal MCT1 inhibitory activity in MCT1-expressing BT20 cells (IC50 value of 24 µM).
Molecular Weight:
426.89
Purity:
97.48%
CAS Number:
[2230186-18-0]
Formula:
C23H23ClN2O4
Target:
Monocarboxylate transporter
T60165
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