RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Poltheta), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Poltheta. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1].
Molecular Weight:
497.37
Purity:
98.34%
CAS Number:
[2832047-80-8]
Formula:
C22H14F7N5O
Target:
DNA/RNA Synthesis
T60187
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