RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 µM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 strongly inhibits biofilm formation in both static and dynamic environments and reduces the production of virulence factors, such as rhamnolipid and pyocyanin, in P. aeruginosa. These characteristics make RhlR antagonist 1 a valuable tool for the development of molecules that modulate quorum sensing and control P. aeruginosa infections [1].
Molecular Weight:
208.2
Formula:
C12H10F2O
Target:
Antibacterial|||Others
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