EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 µM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional regulation of SMYD3 target genes.EM127 slowly reduces methyltransferase activity over a long period of time.EM127 has potential anticancer activity and can be used to study SMYD3 positive tumors. EM127 has potential anticancer activity and can be used to study SMYD3 positive tumors.
Molecular Weight:
311.76
Purity:
0.9761
CAS Number:
[1886879-71-5]
Formula:
C14H18ClN3O3
Target:
ERK|||Histone Methyltransferase
T60777
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