NF-kappaB-IN-4 (compound 17) is a potent inhibitor of the NF-kappaB pathway that can cross the blood-brain barrier (BBB). It exhibits potential anti-neuroinflammatory activity with low toxicity, making it suitable for researching neuroinflammation-related diseases. NF-kappaB-IN-4 can block IkappaBalpha activation and phosphorylation, reduce NLRP3 expression, and thereby inhibit NF-kappaB activation [1].
Molecular Weight:
322.34
Formula:
C18H15FN4O
Target:
Others|||Apoptosis|||NF-kappaB
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