(R)-Lunresertib is the enantiomer of the PKMYT1 inhibitor RP-6306, which negatively regulates CDK1 via phosphorylation of threonine 14 and cytoplasmic sequestration. (R)-Lunresertib demonstrates single-agent antitumor efficacy in CCNE1-amplified xenograft models and shows synergistic effects with gemcitabine in CCNE1-amplified or overexpressing cell lines, providing a critical tool in cancer pharmacology and precision oncology research.
Molecular Weight:
324.38
Purity:
99.09%
CAS Number:
[2719793-91-4]
Formula:
C18H20N4O2
Target:
Wee1
T60886
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