GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so GSK-1482160 has the potential to study inflammatory diseases. GSK-1482160 shows excellent in vitro potency (in functional and electrophysiological assays at recombinant and naive P2X7 receptors across multiple species including humans) and cross-target selectivity.
Molecular Weight:
334.72
Purity:
99.87%
CAS Number:
[1001389-72-5]
Formula:
C14H14ClF3N2O2
Target:
P2X Receptor
T61025
* VAT and and shipping costs not included. Errors and price changes excepted
