TP0427736 hydrochloride is a novel and selective ALK5 inhibitor with an IC50 of 2.72 nM, capable of inhibiting Smad2/3 phosphorylation in A549 cells, reducing TGF-beta-induced growth inhibition of human root sheath cells, and prolonging the anagen phase of mouse hair follicles.
Molecular Weight:
334.85
Purity:
98.99%
CAS Number:
[2459963-17-6]
Formula:
C14H11ClN4S2
Target:
TGF-beta/Smad|||ALK
T61029
T61029
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