AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong inhibitory effects on the production of IL-6, TNF-alpha, IFN-gamma, IL-10, and IL-17A.
Molecular Weight:
339.4
CAS Number:
[1370544-73-2]
Formula:
C21H22FNO2
Target:
Others|||IFNAR|||TNF|||Interleukin
T61071
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