FLT3-IN-13 (compound 20) is a highly effective inhibitor targeting both topoisomerase II and FLT3 proteins in leukemic cells, with IC50 values of 2.26 µM for both. It induces cell cycle arrest at the G2/M phase, promotes apoptosis, and displays considerable anticytotoxic activity specifically against leukemia [1].
Molecular Weight:
342.35
Formula:
C20H14N4O2
Target:
Others|||Topoisomerase|||Apoptosis|||FLT
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