Pentagamavunon-1 (PGV-1) is an oral Curcumin analog that effectively induces apoptosis through multiple molecular mechanisms. It primarily targets and inhibits key angiogenic factors, including cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF), which play crucial roles in mediating cell proliferation and survival. Additionally, PGV-1 possesses the ability to inhibit the activation of NF-kappaB, further enhancing its apoptotic effects. [1]
Molecular Weight:
348.43
CAS Number:
[27060-70-4]
Formula:
C23H24O3
Target:
Others|||COX|||VEGFR|||Apoptosis|||NF-kappaB
T61181
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