VEGFR-2/DHFR-IN-2 (compound 5b) is a dual inhibitor targeting VEGFR-2 and DHFR, with respective IC50 values of 0.623 µM and 9.085 µM. It demonstrates potent cytotoxicity against C26, HepG2, and MCF7 cancer cell lines, with IC50 values ranging from 3.59 µM to 8.38 µM. VEGFR-2/DHFR-IN-2 holds promise for cancer research [1].
