Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative acting as a Type II DNA topoisomerase (topo II) inhibitor. It specifically targets topo IIalpha/beta subtypes, with IC50 values of 0.17 µM for topo IIalpha and 0.23 µM for topo IIbeta, causing significant DNA damage and inducing apoptosis by triggering the loss of mitochondrial membrane potential [1].
Molecular Weight:
356.38
CAS Number:
[99140-25-7]
Formula:
C18H20N4O4
Target:
Apoptosis|||Topoisomerase|||Others
T61283
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