HIV-1 inhibitor-30 (compound 10i) is a potent inhibitor of HIV-1, specifically targeting the RT DNA polymerase enzyme, showing strong antiretroviral activity with an EC50 value of 40 nM and an IC50 value of 80 nM. Moreover, it demonstrates significant effectiveness against seven NNRTI-resistant strains of HIV-1 (RT-K103N, RT-Y181C, RT-K103N, Y181C, RT-L100I, K103N, RT-Y188L, RT-K103N, G190A, RT-K103N, V108I), with IC50 values from 0.04 to 1.42 µM. This compound holds potential for AIDS research [1].
Molecular Weight:
357.83
CAS Number:
[2132412-77-0]
Formula:
C19H20ClN3O2
Target:
Others|||HIV Protease
T61311
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