VO-OHPic is a reversible, noncompetitive, and selective inhibitor of PTEN with an IC50 of 46 nM, effectively attenuating apoptosis, adverse cardiac remodeling, and the presence of pro-inflammatory M1 macrophages in models of doxorubicin-induced cardiomyopathy. Additionally, VO-OHPic inhibits autophagy [1] [2] [3].
Molecular Weight:
361.16
CAS Number:
[675848-25-6]
Formula:
C12H10N2O8V
Target:
Others|||Autophagy|||PTEN|||Apoptosis
T61344
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