SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 µM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. By inhibiting SHP2-mediated cell signal transduction and impairing cancer cell proliferation, SHP2-IN-9 effectively suppresses the growth of both cervix cancer tumors and glioblastoma in vivo [1].
Molecular Weight:
385.46
Formula:
C20H20FN3O2S
Target:
Others|||Phosphatase
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