PD-1/PD-L1-IN 6 (compound A13) is a potent inhibitor of PD-1/PD-L1 interaction (IC50 = 132.8 nM) with outstanding immunoregulatory activity. In a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, PD-1/PD-L1-IN 6 significantly elevates interferon-gamma secretion without significant toxic effects. Additionally, in a T cell-tumor co-culture model, PD-1/PD-L1-IN 6 restores the immune response.
Molecular Weight:
402.49
CAS Number:
[2393983-76-9]
Formula:
C25H26N2O3
Target:
Others|||PD-1/PD-L1
T61968
* VAT and and shipping costs not included. Errors and price changes excepted
