pan-HER-IN-1 (Compound C5) is an irreversible, orally active Pan-HER inhibitor that exhibits IC50 values of 0.38 nM for EGFR, 1.6 nM for HER4, 2.2 nM for EGFR T790M/L858R, and 3.5 nM for HER2, respectively. pan-HER-IN-1 induces apoptosis and demonstrates antitumor activities.
Molecular Weight:
408.25
CAS Number:
[1639040-94-0]
Formula:
C19H14BrN5O
Target:
EGFR|||Apoptosis|||Others
T62047
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