LPM4870108 is a potent, orally active pan-Trk (WT/MT) inhibitor that acts on TrkC (IC50: 0.2 nM), TrkA (IC50: 2.4 nM), TrkAG595R (IC50: 3.5 nM) and TrkAG667C (IC50: 2.3 nM), and is more selective for Trk than ALK (IC50: 2.3 nM). LPM4870108 showed anti-tumour effects.
Molecular Weight:
410.4
Formula:
C20H19FN6O3
Target:
Others|||Trk receptor
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