NLRP3-IN-8 (compound 27), an orally active NLRP3 inflammasome inhibitor, directly binds to its target with an IC50 of 1.23 µM for IL-1beta inhibition. It demonstrates robust metabolic stability in liver microsomes (t1/2 = 138.63 min) and exhibits minimal toxicity (against L02: IC50 > 100 µM) [1].
Molecular Weight:
420.41
CAS Number:
[2768650-56-0]
Formula:
C23H20N2O6
Target:
Others|||NOD-like Receptor (NLR)
T62221
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