HDAC-IN-46 (compound 12c) is a potent inhibitor of HDAC, targeting HDAC1 (IC50: 0.21 µM) and HDAC6 (IC50: 0.021 µM). It upregulates p-p38, downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells, blocks the cell cycle in the G2 phase, and induces apoptosis, making it useful for triple negative breast cancer (TNBC) studies.
Molecular Weight:
438.53
CAS Number:
[2562386-85-8]
Formula:
C22H30N8O2
Target:
Apoptosis|||Others|||HDAC
T62514
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