BS-181 dihydrochloride is a selective and potent inhibitor of CDK7 with an IC50 value of 21 nM. BS-181 dihydrochloride inhibits CDK2 (IC50: 880 nM), CDK5 (IC50: 3000 nM) and CDK9 (IC50: 4200 nM), but does not block CDK1, 4 and 6. BS-181 dihydrochloride inhibits the growth of a group of cancer cells (IC50: 11.5 µM-37.3 µM) and induces apoptosis.
Molecular Weight:
453.46
CAS Number:
[1883548-83-1]
Formula:
C22H34Cl2N6
Target:
Others|||CDK
T62774
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