GNF2133 hydrochloride is a selective, effective, and orally active DYRK1A inhibitor, able to act on DYRK1A (IC50: 0.0062 µM) and GSK3beta (IC50> 50 µM), GNF2133 hydrochloride showed good proliferative ability and efficacy in rat and human primary beta cells. GNF2133 hydrochloride significantly improved glucose processing ability and increased insulin secretion. GNF2133 hydrochloride has the potential to study type 1 diabetes.
Molecular Weight:
471
CAS Number:
[2561414-57-9]
Formula:
C24H31ClN6O2
Target:
DYRK|||Others
T63040
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