CDK6/PIM1-IN-1 is a balanced, potent dual inhibitor of CDK6 (IC50: 39 nM) and PIM1 (IC50: 88 nM), also showing inhibitory activity on CDK4 (IC50: 3.6 nM). It significantly inhibits the proliferation of acute myeloid leukemia (AML) cells, arrests the cell cycle in G1 phase, induces cell apoptosis, and demonstrates anti-AML activity.
Molecular Weight:
473.55
CAS Number:
[2677026-14-9]
Formula:
C25H28FN9
Target:
Apoptosis|||Others|||CDK|||Pim
T63071
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