ZLMT-12 (compound 35) is a tacrine derivative and a potent inhibitor of CDK2 (IC50: 0.011 µM) and CDK9 (IC50: 0.002 µM). ZLMT-12 weakly inhibits AChE (IC50: 19.023 µM) and BuChE (IC50: 2.768 µM). ZLMT-12 has anti-proliferative activity and low cytotoxicity. ZLMT-12 blocks the cell cycle in S-phase and G2/M-phase and induces apoptosis.
Molecular Weight:
479.02
Formula:
C26H31ClN6O
Target:
Apoptosis|||Cholinesterase (ChE)|||Others|||CDK
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