MS8511, a selective covalent irreversible inhibitor of G9a/GLP, targets a cysteine residue at the substrate binding site, displaying IC50 values of 100 nM (G9a) and 140 nM (GLP), alongside Kd values of 44 nM (G9a) and 46 nM (GLP). This compound effectively reduces cellular H3K9me2 levels and boosts antiproliferation activity, making it applicable in cancer research involving brain, breast, ovarian, lung, bladder, melanoma, and colorectal cancers, as well as studies on Alzheimers disease (AD), sickle cell disease, and Prader-Willi syndrome (PWS) [1].
Molecular Weight:
495.66
CAS Number:
[2866408-21-9]
Formula:
C28H41N5O3
Target:
Histone Methyltransferase|||Others
T63351
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