NRX-252114 (NRX252114) induces degradation of mutant beta-catenin NRX-252114 is a potent enhancer of the interaction of beta-catenin with the homologous E3 ligase SCFbeta-TrCP, and is able to enhance the binding of pSer33/S37A beta-catenin to beta-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. Kd is 0.4 nM.
Molecular Weight:
510.32
Purity:
98.13%
CAS Number:
[2763260-39-3]
Formula:
C22H12Cl2F3N3O2S
Target:
Molecular Glues|||Wnt/beta-catenin
T63516
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