Gefitinib dihydrochloride is a potent, selective, orally active EGFR tyrosine kinase inhibitor (IC50: 33 nM). Gefitinib dihydrochloride selectively inhibits EGF-stimulated tumor cell growth with an IC50 value of 54 nM and blocks EGFR autophosphorylation in EGF-stimulated tumor cells. Gefitinib dihydrochloride induces autophagy and apoptosis, and can be used in studies of cancer-related diseases such as lung and breast cancer.
Molecular Weight:
519.82
CAS Number:
[184475-56-7]
Formula:
C22H26Cl3FN4O3
Target:
Others|||Apoptosis|||Autophagy|||EGFR
T63630
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