XP-524 is a potent inhibitor of BET and EP300. XP-524 has significant tumouricidal effects in vivo, preventing KRAS-induced tumour transformation in vivo and prolonging survival in two aggressive PDAC transgenic mouse models. XP-524 also enhances the expression of its own peptide and recruitment of tumour cells to cytotoxic T lymphocytes. XP-524 has shown potential for research in pancreatic ductal adenocarcinoma (PDAC).
Molecular Weight:
552.65
CAS Number:
[2344825-52-9]
Formula:
C30H28N6O3S
Target:
Kras|||Ras|||Others|||Epigenetic Reader Domain
T63902
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