DI-1859 is a selective, potent and covalent inhibitor of DCN1. At low nanomolar concentrations, DI-1859 inhibits the neddylation of cullin 3 in cells. DI-1859 induces a significant increase in NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver injury.
Molecular Weight:
555.78
CAS Number:
[2247061-09-0]
Formula:
C30H45N5O3S
Target:
Others|||E1/E2/E3 Enzyme
T63930
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