GRPR antagonist-1 is a potent antagonist of the gastrin-releasing peptide receptor (GRPR) and displays cytotoxicity to certain cancer cells, including PC3 cells (IC50: 4.97 µM), Pan02 cells (IC50: 4.36 µM), and HGC-27 cells (IC50: 3.40 µM). It reduces Bcl-2 levels, increases Bax levels, inhibits HGC-27 cell viability, and induces apoptosis, thereby exhibiting anti-cancer effects.
Molecular Weight:
558.59
Formula:
C29H33F3N4O4
Target:
Others|||Bombesin Receptor
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