KIRA9 is a potent inhibitor of IRE1 with an IC50 value of 4.8 µM for INS-1 cells. KIRA9 completely binds the ATP binding site of IRE1 and blocks endoplasmic reticulum (ER) localised mRNA decay and apoptosis.
Molecular Weight:
572.6
Formula:
C27H27F3N6O3S
Target:
Others|||Apoptosis|||IRE1
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